Biointerfaces beyond neurons, bioinspiration beyond homeostasis
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Building the MOSAIC
THEORY
1. Starting from systems biology as a fundamental model to represent organism operation
GOALS
2. Decoding its patterns by uncovering cell signaling - the language of cells - for medical applications
3. Emulating its patterns to develop multiscale intelligence artificial systems
METHODS
1. Automating biological experiments through engineering
2. Using nanotechnology to develop bespoke platforms for electromechanical cellular interrogation
3. Mapping cellular behavior using advanced signal processing methods
4. Developing research tools to inform experimental design and data interpretation
5. Manipulating cellular signaling for medical applications
6. Designing new bioinspired engineering models
READINGS
Moreddu, R. (2025). Pathology from a complex systems perspective: an umbrella of paradigms for bioinspired engineering beyond homeostasis. Read it here.
Cadinu, P., Moreddu, R., et al. (2025). Bioelectrical interfaces beyond cellular excitability: cancer, aging, and gene expression reprogramming. Read it here.
Melikov, R., Moreddu, R., et al. (2024). Microelectrodes record the electrical activity of metastatic breast cancer cells in vitro. Read it here.
Moreddu, R. et al. (2023). Passive recording of bioelectrical signals from non-excitable cells by fluorescent mirroring. Read it here.
Moreddu, R., Levin, M. (2025). Cancermorphic computing toward multilevel machine intelligence. Read it here.
Moreddu, R. (2024). Nanotechnology and cancer bioelectricity: bridging the gap between biology and translational medicine. Read it here.
Moreddu, R. (2025). Interactive databases for the life sciences. Read it here.
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